Quick Answer:

No, TrainMaster 4.3 will not work on Windows Vista, and unfortunately we do not have any plans to support it in the future.

Further Details:

The Reasoning Behind the Decision:

The retail version of TrainMaster was first released in 1995, and was created by TrainMaster, Inc. P.I. Engineering eventually purchased the rights to the simulator, and updated it to it's final version 4.3, which added support for our RailDriver Desktop Train Cab Controller.

Due to the age of this simulator and the fact that we did not create the original simulator, we are unable to update the program so that it will work on Windows Vista.